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(Created page with "'''Alpha-fetoprotein''', abbreviated '''AFP''', is plasma protein seen in fetal life and produced by various tumours. ==Elevated AFP - classic causes== *Yolk sac tumour....") |
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{{ Infobox immunostain | |||
| Name = {{PAGENAME}} | |||
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| Abbrev = AFP | |||
| Synonyms = | |||
| Similar = | |||
| Clones = | |||
| Use = | |||
| Subspecial = [[genitourinary pathology]], [[gastrointestinal pathology]] | |||
| Pattern = | |||
| Positive = [[yolk sac tumour]], [[hepatocellular carcinoma]] | |||
| Negative = | |||
| Other = common serum tumour marker | |||
}} | |||
'''Alpha-fetoprotein''', abbreviated '''AFP''', is plasma protein seen in fetal life and produced by various tumours. | '''Alpha-fetoprotein''', abbreviated '''AFP''', is plasma protein seen in fetal life and produced by various tumours. | ||
==Elevated AFP - classic causes== | ==Elevated AFP - classic causes== | ||
*[[Yolk sac tumour]]. | *[[Yolk sac tumour]]. | ||
*[[Hepatocellular carcinoma]]. | *[[Hepatocellular carcinoma]].<ref name=pmid26157947>{{Cite journal | last1 = Ip | first1 = S. | last2 = Schaeffer | first2 = DF. | last3 = Yoshida | first3 = EM. | last4 = Kwan | first4 = WP. | title = Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy. | journal = ACG Case Rep J | volume = 2 | issue = 3 | pages = 152-4 | month = Apr | year = 2015 | doi = 10.14309/crj.2015.38 | PMID = 26157947 }}</ref> | ||
==Uncommon== | ==Uncommon== | ||
*[[Rectal carcinoma]].<ref name=pmid25962419>{{Cite journal | last1 = Anzai | first1 = H. | last2 = Kazama | first2 = S. | last3 = Kiyomatsu | first3 = T. | last4 = Nishikawa | first4 = T. | last5 = Tanaka | first5 = T. | last6 = Tanaka | first6 = J. | last7 = Hata | first7 = K. | last8 = Kawai | first8 = K. | last9 = Yamaguchi | first9 = H. | title = Alpha-fetoprotein-producing early rectal carcinoma: a rare case report and review. | journal = World J Surg Oncol | volume = 13 | issue = | pages = 180 | month = | year = 2015 | doi = 10.1186/s12957-015-0590-x | PMID = 25962419 }}</ref> | *[[Rectal carcinoma]].<ref name=pmid25962419>{{Cite journal | last1 = Anzai | first1 = H. | last2 = Kazama | first2 = S. | last3 = Kiyomatsu | first3 = T. | last4 = Nishikawa | first4 = T. | last5 = Tanaka | first5 = T. | last6 = Tanaka | first6 = J. | last7 = Hata | first7 = K. | last8 = Kawai | first8 = K. | last9 = Yamaguchi | first9 = H. | title = Alpha-fetoprotein-producing early rectal carcinoma: a rare case report and review. | journal = World J Surg Oncol | volume = 13 | issue = | pages = 180 | month = | year = 2015 | doi = 10.1186/s12957-015-0590-x | PMID = 25962419 }}</ref> | ||
*[[Gastric carcinoma]].<ref name=pmid26157947>{{Cite journal | last1 = Ip | first1 = S. | last2 = Schaeffer | first2 = DF. | last3 = Yoshida | first3 = EM. | last4 = Kwan | first4 = WP. | title = Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy. | journal = ACG Case Rep J | volume = 2 | issue = 3 | pages = 152-4 | month = Apr | year = 2015 | doi = 10.14309/crj.2015.38 | PMID = 26157947 }}</ref><ref>{{cite journal |authors=Tatli AM, Urakci Z, Kalender ME, Arslan H, Tastekin D, Kaplan MA |title=Alpha-fetoprotein (AFP) elevation gastric adenocarcinoma and importance of AFP change in tumor response evaluation |journal=Asian Pac J Cancer Prev |volume=16 |issue=5 |pages=2003–7 |date=2015 |pmid=25773802 |doi=10.7314/apjcp.2015.16.5.2003 |url=}}</ref> | |||
==See also== | ==See also== | ||
*[[Germ cell tumours]]. | *[[Germ cell tumours]]. | ||
*[[Pregnancy]]. | |||
==References== | ==References== | ||