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Diverticular disease (view source)

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→‎Biopsy with possible diverticular disease-associated colitis
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#redirect [[Colon#Diverticular_disease]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Diverticulum_-_very_low_mag.jpg
| Width      =
| Caption    = Diverticulum. [[H&E stain]].
| Micro      = mucosa/submucosa invaginate into the musuclaris propria
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = outpouching - best seen after sectioning
| Grossing  = [[partial colectomy for diverticular disease]]
| Site      = [[colon]] - classically sigmoid, other sites
| Assdx      = diverticulitis, [[peritonitis]], diverticular disease-associated [[colitis]]
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  = usu. asymptomatic, diverticulitis presents with abdominal pain - classically left lower quadrant
| Prevalence = common - especially elderly
| Bloodwork  =
| Rads      = colonic outpouchings (typically sigmoid colon) +/-pericolic stranding
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    = [[colorectal carcinoma]], [[epiploic appendagitis]]
| Tx        = usually conservative, surgical resection (recurrent or perforating diverticulitis)
}}
'''Diverticular disease''', also '''diverticulosis''', is a common disease of the [[colon]]. Inflammation of diverticula is known as '''diverticulitis'''.
 
==General==
*Very common.
*Typically seen in elderly patients - 50s and 60s.
*Weakly associated with adenomatous polyps (odd ratio ~ 1.03) - probably due to shared causality (i.e. diet).<ref name=pmid2486634>{{Cite journal  | last1 = Lim | first1 = YJ. | last2 = Nanto | first2 = S. | last3 = Masuyama | first3 = T. | last4 = Kohama | first4 = A. | last5 = Kodama | first5 = K. | last6 = Kitabatake | first6 = A. | last7 = Kamada | first7 = T. | title = [Evaluation of function of human collateral coronary arteries using myocardial contrast echocardiography]. | journal = J Cardiol | volume = 19 | issue = 4 | pages = 973-9 | month = Dec | year = 1989 | doi =  | PMID = 2486634 }}</ref>
 
Presentations:
*Incidental finding on imaging.
*Abdominal pain.
**Classically left lower quadrant.
**+/-Peritoneal signs.
*Blood per rectum.
*[[Large bowel obstruction]].
 
Complications:
*Diverticulitis - seen in ~25% of individuals with divertiulosis.<ref name=pmid25253951>{{Cite journal  | last1 = Agarwal | first1 = AK. | last2 = Karanjawala | first2 = BE. | last3 = Maykel | first3 = JA. | last4 = Johnson | first4 = EK. | last5 = Steele | first5 = SR. | title = Routine colonic endoscopic evaluation following resolution of acute diverticulitis: is it necessary? | journal = World J Gastroenterol | volume = 20 | issue = 35 | pages = 12509-16 | month = Sep | year = 2014 | doi = 10.3748/wjg.v20.i35.12509 | PMID = 25253951 }}</ref>
*Peformation - [[peritonitis]].
*Diverticular-associated colitis - see below.
*Bowel obstruction - not common, may mimic malignancy.<ref name=pmid15143223>{{Cite journal  | last1 = Pereira | first1 = JM. | last2 = Sirlin | first2 = CB. | last3 = Pinto | first3 = PS. | last4 = Jeffrey | first4 = RB. | last5 = Stella | first5 = DL. | last6 = Casola | first6 = G. | title = Disproportionate fat stranding: a helpful CT sign in patients with acute abdominal pain. | journal = Radiographics | volume = 24 | issue = 3 | pages = 703-15 | month =  | year =  | doi = 10.1148/rg.243035084 | PMID = 15143223 }}</ref>
 
===Diverticular disease-associated colitis===
Features:<ref name=pmid19581849>{{Cite journal  | last1 = Mulhall | first1 = AM. | last2 = Mahid | first2 = SS. | last3 = Petras | first3 = RE. | last4 = Galandiuk | first4 = S. | title = Diverticular disease associated with inflammatory bowel disease-like colitis: a systematic review. | journal = Dis Colon Rectum | volume = 52 | issue = 6 | pages = 1072-9 | month = Jun | year = 2009 | doi = 10.1007/DCR.0b013e31819ef79a | PMID = 19581849 }}</ref>
*Rare.
*Definitions vary somewhat - one is: ''[[IBD]]-like inflammation restricted to areas with diverticular disease''.
*Considerable overlap with IBD histologically - no definite histologic findings.
*Rectal biopsy may be used to differentiate from [[ulcerative colitis]].
 
==Gross==
*Corrugated - like cardboard.
*Wall thickening (reactive).<ref name=pmid21359889>{{Cite journal  | last1 = Nicholson | first1 = BD. | last2 = Hyland | first2 = R. | last3 = Rembacken | first3 = BJ. | last4 = Denyer | first4 = M. | last5 = Hull | first5 = MA. | last6 = Tolan | first6 = DJ. | title = Colonoscopy for colonic wall thickening at computed tomography: a worthwhile pursuit? | journal = Surg Endosc | volume = 25 | issue = 8 | pages = 2586-91 | month = Aug | year = 2011 | doi = 10.1007/s00464-011-1591-7 | PMID = 21359889 }}</ref>
*Usually sigmoid colon.
**May be elsewhere, e.g. appendix.<ref name=pmid23323233>{{Cite journal  | last1 = Sohn | first1 = TJ. | last2 = Chang | first2 = YS. | last3 = Kang | first3 = JH. | last4 = Kim | first4 = DH. | last5 = Lee | first5 = TS. | last6 = Han | first6 = JK. | last7 = Kim | first7 = SH. | last8 = Hong | first8 = YO. | title = Clinical characteristics of acute appendiceal diverticulitis. | journal = J Korean Surg Soc | volume = 84 | issue = 1 | pages = 33-7 | month = Jan | year = 2013 | doi = 10.4174/jkss.2013.84.1.33 | PMID = 23323233 }}</ref>
===Images===
<gallery>
Image:Diverticulosis_2.jpg | Diverticular disease. (WC/Samir)
Image:Sigmoid diverticulum (diagram).jpg | Drawing of sigmoid diverticula. (WC/Anpol42)
</gallery>
<!--===Radiologic===
*Bowel wall thickening<ref name=pmid3741003>{{Cite journal  | last1 = Morris | first1 = J. | last2 = Stellato | first2 = TA. | last3 = Lieberman | first3 = J. | last4 = Haaga | first4 = JR. | title = The utility of computed tomography in colonic diverticulitis. | journal = Ann Surg | volume = 204 | issue = 2 | pages = 128-32 | month = Aug | year = 1986 | doi =  | PMID = 3741003 }}</ref> -->
 
==Microscopic==
Features:
*Mucosa/submucosa invagination into the musuclaris propria (MP).
**At the site the blood vessels supplying the mucosa and submucosa penetrate the MP.<ref name=pmid18936652>{{Cite journal  | last1 = West | first1 = AB. | title = The pathology of diverticulitis. | journal = J Clin Gastroenterol | volume = 42 | issue = 10 | pages = 1137-8 | month =  | year =  | doi = 10.1097/MCG.0b013e3181862a9f | PMID = 18936652 }}</ref>
 
Notes:
*Crypt disortion and/or [[granuloma]]s should '''not''' be seen.<ref name=pmid9124212>{{Cite journal  | last1 = Goldstein | first1 = NS. | last2 = Ahmad | first2 = E. | title = Histology of the mucosa in sigmoid colon specimens with diverticular disease: observations for the interpretation of sigmoid colonoscopic biopsy specimens. | journal = Am J Clin Pathol | volume = 107 | issue = 4 | pages = 438-44 | month = Apr | year = 1997 | doi =  | PMID = 9124212 }}</ref>
 
DDx:
*[[Colorectal carcinoma]] - may cause a stricture, usually obvious on microscopy.
*[[Inflammatory bowel disease]].
 
===Images===
<gallery>
Image:Colon diverticulosis whole slide.jpg |Diverticular disease. (WC)
</gallery>
www:
*[http://histology-group28.wikispaces.com/file/view/divertic.jpg/60992930/divertic.jpg DD (wikispaces.com)].<ref>URL: [http://histology-group28.wikispaces.com/DigestiveSystemProject http://histology-group28.wikispaces.com/DigestiveSystemProject]. Accessed on: 23 August 2011.</ref>
 
==Sign out==
''Sternberg's Diagnostic Surgical Pathology'' suggests using the term ''diverticular disease'' instead of trying to distinguish between ''diverticulosis'' and ''diverticulitis'', as ''diverticulitis'' clinically may be seen without objective evidence of inflammation.<ref>{{Ref Sternberg5|1346}}</ref>
*This is reasonable, considering that (1) sampling in large specimens may miss the definite active inflammation, and (2) the distinction is academic, as the management is not driven by this detail of the pathologic findings.
 
<pre>
Sigmoid Colon, Sigmoidectomy:
- Diverticular disease with surrounding fibrosis and small focus of
  active mucosal inflammation.
- Four benign lymph nodes.
- NEGATIVE for malignancy.
</pre>
 
===Block letters===
<pre>
SIGMOID COLON, SIGMOIDECTOMY:
- DIVERTICULAR DISEASE WITHOUT EVIDENCE OF ACTIVE DIVERTICULITIS.
- NEGATIVE FOR MALIGNANCY.
</pre>
 
<pre>
SIGMOID COLON WITH EEA DONUTS, SIGMOIDECTOMY:
- DIVERTICULAR DISEASE WITHOUT EVIDENCE OF ACTIVE DIVERTICULITIS.
- ONE BENIGN SMALL LYMPH NODE.
- NEGATIVE FOR MALIGNANCY.
</pre>
 
====Perforated====
<pre>
RECTO-SIGMOID, LARGE BOWEL RESECTION:
- PERFORATED DIVERTICULITIS WITH SEROSITIS AND ABSCESS FORMATION.
- SUBMUCOSAL FIBROSIS.
- ONE LYMPH NODE NEGATIVE FOR MALIGNANCY ( 0 POSITIVE / 1 ).
- NEGATIVE FOR MALIGNANCY.
</pre>
 
<pre>
SIGMOID COLON, RESECTION:
- COLONIC PERFORATION ASSOCIATED WITH FAT NECROSIS, SEROSITIS AND MICROABSCESS
  FORMATION, IN THE SETTING OF DIVERTICULAR DISEASE.
- ONE LYMPH NODE NEGATIVE FOR MALIGNANCY ( 0 POSITIVE / 1 ).
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
</pre>
 
===Biopsy with possible ''diverticular disease-associated colitis''===
<pre>
The endoscopy report describes diverticular disease. The general differential diagnosis for histologic colitis (infection, inflammatory conditions, ischemia, iatrogenic causes) should be considered.
 
Inflammation restricted to areas with diverticular disease may be "diverticular disease-associated colitis". Clinical correlation is required.
</pre>
 
==See also==
*[[Colon]].
*[[Gastrointestinal pathology]].
*[[Inflammatory bowel disease]] (IBD).
*[[Diversion colitis]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Colon]]
[[Category:Gastrointestinal pathology]]
Michael
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