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| ==Cutaneous T-cell lymphoma== | | ==Cutaneous T-cell lymphoma== |
| *Abbreviated CTCL. | | *Abbreviated CTCL. |
| | | {{Main|Cutaneous T-cell lymphoma}} |
| ===General===
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| *''Mycosis fungoides'' - is a subtype (???).
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| *CTCL is more common than cutaneous B-cell lymphoma (CBCL).<ref>URL: [http://emedicine.medscape.com/article/1099540-overview http://emedicine.medscape.com/article/1099540-overview]. Accessed on: 24 August 2010.</ref><ref>URL: [http://emedicine.medscape.com/article/1098342-overview http://emedicine.medscape.com/article/1098342-overview]. Accessed on: 24 August 2010.</ref>
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| Stages - like [[Kaposi sarcoma]]:
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| *Patch.
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| *Plaque.
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| *Nodular.
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| ===Microscopic===
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| *Atypical lymphocytes:
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| **Have folded "cerebriform" nuclei; ''Sezary-Lutzner cells''.<ref name=Ref_Klatt385>{{Ref Klatt|385}}</ref>
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| *Grouping:
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| **Nests in the epidermis - known as "Pautrier microabscesses".
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| **Single lymphocytes in epidermis - without accompanying edema.
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| **Short linear arrays of lymphocytes along the basal layer of the epidermis; "epidermotropism".<ref name=Ref_Klatt385>{{Ref Klatt|385}}</ref>
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| DDx:
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| *[[Lymphomatoid papulosis]].
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| ====Images====
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| <gallery>
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| Image:Cutaneous_T-cell_lymphoma_-_very_high_mag.jpg | CTCL - very high mag. (WC/Nephron)
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| Image:Cutaneous_T-cell_lymphoma_-_intermed_mag.jpg | CTCL - intermed. mag. (WC/Nephron)
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| </gallery>
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| www:
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| *[http://www.jci.org/articles/view/24826/figure/2 CTCL (jci.org)].
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| *[http://www.mdconsult.com/das/book/body/199872830-2/0/1709/I4-u1.0-B978-0-443-06694-8..50117-2--f2.fig CTCL (mdconsult.com)].
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| ===IHC===
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| Key stain:
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| *CD4 +ve.<ref>{{Ref PBoD8|1185}}</ref>
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| Other stains:
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| *CD3 +ve.
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| *CD8 -ve.
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| *CD20 -ve (to r/o significant B cell population).
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| *CD30 -ve.
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| *CD5 +ve.
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| *CD7 -ve (often lost first in T cell lymphomas).
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| *Ki-67 high.
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| *CD56 -ve.
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| ==Merkel cell carcinoma== | | ==Merkel cell carcinoma== |
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| Images: | | Images: |
| *[http://archive.ispub.com/journal/the-internet-journal-of-dermatology/volume-7-number-1/cutaneous-mixed-tumor.article-g01.fs.jpg Chondroid syringoma - low mag. (ispub.com)].<ref name=ispub_mts>URL: [http://www.ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html http://www.ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html]. Access on: 21 September 2011.</ref> | | *[https://www.dermnetnz.org/topics/apocrine-mixed-tumour-pathology Chondroid syringoma (DermnetNZ)]. |
| *[http://archive.ispub.com/journal/the-internet-journal-of-dermatology/volume-7-number-1/cutaneous-mixed-tumor.article-g02.fs.jpg Chondroid syringoma - high mag. (ispub.com)].<ref name=ispub_mts>URL: [http://www.ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html http://www.ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html]. Access on: 21 September 2011.</ref>
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| ==Dermal cylindroma== | | ==Dermal cylindroma== |
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| {{Main|Trichilemmoma}} | | {{Main|Trichilemmoma}} |
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| ==Eccrine poroma== | | ==Poroma== |
| ===General===
| | {{Main|Poroma}} |
| *Benign tumour arising from the distal sweat duct.
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| *Erythematous - gross.
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| ===Microscopic===
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| Features:<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70190-5 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70190-5]. Accessed on: 2 July 2010.</ref>
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| *Broad sheets of basaloid cells - attached to the epidermis - containing ductal structures - '''key feature'''.
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| *Biphasic stroma:
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| *#Edematous stroma.
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| *#Sclerotic stroma.
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| *Moderate nuclear pleomorphism.
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| *+/-Occasional mitoses.
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| Notes:
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| *Area above gland appears crusted.
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| DDx:
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| *[[Trichilemmoma]].
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| *[[Nodular hidradenoma]].
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| ====Images====
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| <gallery>
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| Image: SkinTumors-P7150495.JPG | EP. (WC)
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| </gallery>
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| www:
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| *[http://www.flickr.com/photos/40981620@N04/3808316834/in/photostream/ Eccrine poroma - low mag. (flickr.com)]
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| *[http://www.flickr.com/photos/40981620@N04/3807502071/in/photostream Eccrine poroma - intermed. mag. (flickr.com)].
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| ==Nodular hidradenoma== | | ==Nodular hidradenoma== |