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Difference between revisions of "Glypican 3"
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'''Glypican 3''' is a common [[immunostain]] used in [[gastrointestinal pathology]] and [[ | '''Glypican 3''', abbreviated '''GPC3''',<ref>{{OMIM|300037}}</ref> is a common [[immunostain]] used in [[gastrointestinal pathology]] and [[genitourinary pathology]]. | ||
==Positive== | ==Positive== | ||
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*[[Malignant melanoma]].<ref name=pmid25896897/> | *[[Malignant melanoma]].<ref name=pmid25896897/> | ||
*[[Squamous cell carcinoma of the lung]].<ref name=pmid25896897/> | *[[Squamous cell carcinoma of the lung]].<ref name=pmid25896897/> | ||
**Uncommon in adenocarcinoma of the lung ~3% of cases.<ref name=pmid26345955>{{Cite journal | last1 = Yu | first1 = X. | last2 = Li | first2 = Y. | last3 = Chen | first3 = SW. | last4 = Shi | first4 = Y. | last5 = Xu | first5 = F. | title = Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance. | journal = Genet Mol Res | volume = 14 | issue = 3 | pages = 10185-92 | month = Aug | year = 2015 | doi = 10.4238/2015.August.28.2 | PMID = 26345955 }}</ref> | |||
*[[Yolk sac tumour]]. | *[[Yolk sac tumour]]. | ||
**More sensitive than [[alpha-fetoprotein]] (AFP).<ref name=pmid20438407>{{Cite journal | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref> | |||
===Images=== | ===Images=== | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414302/figure/Fig1/ Glypican 3 in UCC (nih.gov)].<ref name=pmid25896897/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414302/figure/Fig1/ Glypican 3 in UCC (nih.gov)].<ref name=pmid25896897/> | ||
==Positive or negative== | |||
*[[Choriocarcinoma]]. | |||
==See also== | ==See also== | ||