Difference between revisions of "Choriocarcinoma"

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Choriocarcinoma (view source)

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      = Choriocarcinoma_-2-_very_high_mag.jpg  
| Image      = Choriocarcinoma_-2-_very_high_mag.jpg
| Width      =
| Width      =
| Caption    = Choriocarcinoma. [[H&E stain]].
| Caption    = Choriocarcinoma. [[H&E stain]].
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| LMDDx      = [[mixed germ cell tumour]], [[invasive hydatidiform mole]], [[placental site trophoblastic tumour]]
| LMDDx      = [[mixed germ cell tumour]], [[invasive hydatidiform mole]], [[placental site trophoblastic tumour]]
| Stains    =
| Stains    =
| IHC        = beta-hCG +ve, CD10 +ve, OCT3 -ve
| IHC        = beta-hCG +ve, CD10 +ve, p63 +ve, OCT3 -ve
| EM        =
| EM        =
| Molecular  =
| Molecular  =
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| Gross      = dark friable, hemorrhagic/necrotic-appearing mass with an invasive border
| Gross      = dark friable, hemorrhagic/necrotic-appearing mass with an invasive border
| Grossing  = [[orchiectomy grossing]]
| Grossing  = [[orchiectomy grossing]]
| Staging    = [[testicular cancer staging]]
| Site      = [[ovary]], [[testis]], [[uterus]]
| Site      = [[ovary]], [[testis]], [[uterus]]
| Assdx      = [[complete hydatidiform mole]]
| Assdx      = [[complete hydatidiform mole]]
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*Vaginal bleeding or testicular mass.
*Vaginal bleeding or testicular mass.
*Occasionally thyrotoxicosis.<ref name=pmid8395487>{{Cite journal  | last1 = O'Reilly | first1 = S. | last2 = Lyons | first2 = DJ. | last3 = Harrison | first3 = M. | last4 = Gaffney | first4 = E. | last5 = Cullen | first5 = M. | last6 = Clancy | first6 = L. | title = Thyrotoxicosis induced by choriocarcinoma a report of two cases. | journal = Ir Med J | volume = 86 | issue = 4 | pages = 124, 127 | month =  | year =  | doi =  | PMID = 8395487 }}</ref>
*Occasionally thyrotoxicosis.<ref name=pmid8395487>{{Cite journal  | last1 = O'Reilly | first1 = S. | last2 = Lyons | first2 = DJ. | last3 = Harrison | first3 = M. | last4 = Gaffney | first4 = E. | last5 = Cullen | first5 = M. | last6 = Clancy | first6 = L. | title = Thyrotoxicosis induced by choriocarcinoma a report of two cases. | journal = Ir Med J | volume = 86 | issue = 4 | pages = 124, 127 | month =  | year =  | doi =  | PMID = 8395487 }}</ref>
Note:
*Beta-hCG is negative ~3 weeks after pregnancy.<ref name=pmid2436389 >{{Cite journal  | last1 = Haenel | first1 = AF. | last2 = Hugentobler | first2 = W. | last3 = Brunner | first3 = S. | title = [The postpartum course of the HCG titer of maternal blood and its clinical relevance]. | journal = Z Geburtshilfe Perinatol | volume = 190 | issue = 6 | pages = 275-8 | month =  | year =  | doi =  | PMID = 2436389 }}</ref>


===Epidemiology===
===Epidemiology===
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===Images===
===Images===
====Case====
<gallery>
<gallery>
Image: Choriocarcinoma - intermed mag.jpg | Choriocarcinoma - intermed. mag. (WC/Nephron)
Image: Choriocarcinoma - intermed mag.jpg | Choriocarcinoma - intermed. mag. (WC/Nephron)
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Image: Choriocarcinoma -2- very high mag.jpg | Choriocarcinoma - very high mag. (WC/Nephron)
Image: Choriocarcinoma -2- very high mag.jpg | Choriocarcinoma - very high mag. (WC/Nephron)
</gallery>
</gallery>
www:
====Case====
<gallery>
Image: Choriocarcinoma to lung -- low mag.jpg | Choriocarcinoma - low mag. (WC)
Image: Choriocarcinoma to lung -- intermed mag.jpg | Choriocarcinoma - intermed. mag. (WC)
Image: Choriocarcinoma to lung -- high mag.jpg | Choriocarcinoma - high mag. (WC)
Image: Choriocarcinoma to lung - alt -- high mag.jpg | Choriocarcinoma - high mag. (WC)
Image: Choriocarcinoma to lung -- very high mag.jpg | Choriocarcinoma - very high mag. (WC)
</gallery>
====www====
*[http://www.webpathology.com/image.asp?n=5&Case=36 Choriocarcinoma - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=5&Case=36 Choriocarcinoma - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=36&n=1 Choriocarcinoma (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=36&n=1 Choriocarcinoma (webpathology.com)].
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[[ISUP]] consensus paper by Ulbright ''et al.'':<ref name=pmid24832161>{{cite journal |author=Ulbright TM, Tickoo SK, Berney DM, Srigley JR |title=Best practices recommendations in the application of immunohistochemistry in testicular tumors: report from the international society of urological pathology consensus conference |journal=Am. J. Surg. Pathol. |volume=38 |issue=8 |pages=e50–9 |year=2014 |month=August |pmid=24832161 |doi=10.1097/PAS.0000000000000233 |url=}}</ref>
[[ISUP]] consensus paper by Ulbright ''et al.'':<ref name=pmid24832161>{{cite journal |author=Ulbright TM, Tickoo SK, Berney DM, Srigley JR |title=Best practices recommendations in the application of immunohistochemistry in testicular tumors: report from the international society of urological pathology consensus conference |journal=Am. J. Surg. Pathol. |volume=38 |issue=8 |pages=e50–9 |year=2014 |month=August |pmid=24832161 |doi=10.1097/PAS.0000000000000233 |url=}}</ref>
*Beta-hCG +ve.
*Beta-hCG +ve.
*Glypican 3 +ve/-ve.
*[[Glypican 3]] +ve/-ve.
*OCT3 -ve.
*OCT3 -ve.
*AFP -ve.
*AFP -ve.


Others:
Others:
*p63 +ve.<ref name=pmid18318583>{{Cite journal  | last1 = Mittal | first1 = K. | last2 = Soslow | first2 = R. | last3 = McCluggage | first3 = WG. | title = Application of immunohistochemistry to gynecologic pathology. | journal = Arch Pathol Lab Med | volume = 132 | issue = 3 | pages = 402-23 | month = Mar | year = 2008 | doi = 10.1043/1543-2165(2008)132[402:AOITGP]2.0.CO;2 | PMID = 18318583 }}</ref>
**[[Placental site nodule]] and [[epithelioid trophoblastic tumour]] +ve.
**[[Exaggerated placental site]] and [[placental site trophoblastic tumour]] -ve.
*Ki-67 +ve -- typically >30%.
*Ki-67 +ve -- typically >30%.
*CK7 +ve.<ref name=pmid25469347>{{Cite journal  | last1 = Park | first1 = SY. | last2 = Lee | first2 = DE. | last3 = Park | first3 = HJ. | last4 = Kim | first4 = KC. | last5 = Kim | first5 = YH. | title = Retroperitoneal nongestational choriocarcinoma in a 25-year-old woman. | journal = Obstet Gynecol Sci | volume = 57 | issue = 6 | pages = 544-8 | month = Nov | year = 2014 | doi = 10.5468/ogs.2014.57.6.544 | PMID = 25469347 }}</ref><ref name=pmid22091297>{{Cite journal  | last1 = Hemati | first1 = S. | last2 = Esnaashari | first2 = O. | last3 = Mohajeri | first3 = M. | last4 = Sarvizadeh | first4 = M. | title = Choriocarcinoma of the breast; a case report and review of literatures. | journal = J Res Med Sci | volume = 16 | issue = 5 | pages = 707-11 | month = May | year = 2011 | doi =  | PMID = 22091297 }}</ref>
*MUC-4 +ve.<ref name=pmid18059230>{{Cite journal  | last1 = Mao | first1 = TL. | last2 = Kurman | first2 = RJ. | last3 = Huang | first3 = CC. | last4 = Lin | first4 = MC. | last5 = Shih | first5 = IeM. | title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. | journal = Am J Surg Pathol | volume = 31 | issue = 11 | pages = 1726-32 | month = Nov | year = 2007 | doi = 10.1097/PAS.0b013e318058a529 | PMID = 18059230 }}</ref>
*MUC-4 +ve.<ref name=pmid18059230>{{Cite journal  | last1 = Mao | first1 = TL. | last2 = Kurman | first2 = RJ. | last3 = Huang | first3 = CC. | last4 = Lin | first4 = MC. | last5 = Shih | first5 = IeM. | title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. | journal = Am J Surg Pathol | volume = 31 | issue = 11 | pages = 1726-32 | month = Nov | year = 2007 | doi = 10.1097/PAS.0b013e318058a529 | PMID = 18059230 }}</ref>
*CD10 +ve (10 +ve of 10 cases<ref name=pmid19145204>{{Cite journal  | last1 = Kalhor | first1 = N. | last2 = Ramirez | first2 = PT. | last3 = Deavers | first3 = MT. | last4 = Malpica | first4 = A. | last5 = Silva | first5 = EG. | title = Immunohistochemical studies of trophoblastic tumors. | journal = Am J Surg Pathol | volume = 33 | issue = 4 | pages = 633-8 | month = Apr | year = 2009 | doi = 10.1097/PAS.0b013e318191f2eb | PMID = 19145204 }}</ref>).
*CD10 +ve (10 +ve of 10 cases<ref name=pmid19145204>{{Cite journal  | last1 = Kalhor | first1 = N. | last2 = Ramirez | first2 = PT. | last3 = Deavers | first3 = MT. | last4 = Malpica | first4 = A. | last5 = Silva | first5 = EG. | title = Immunohistochemical studies of trophoblastic tumors. | journal = Am J Surg Pathol | volume = 33 | issue = 4 | pages = 633-8 | month = Apr | year = 2009 | doi = 10.1097/PAS.0b013e318191f2eb | PMID = 19145204 }}</ref>).
Michael
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