Difference between revisions of "Placental alkaline phosphatase"

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'''Placental alkaline phosphatase''', abbreviated '''PLAP''', is a common marker used for assessing suspected [[germ cell tumours]].
{{ Infobox immunostain
| Name      = {{PAGENAME}}
| Image      = ITGCN and Sertoli cells only - PLAP -- high mag.jpg
| Width      =
| Caption    = PLAP in [[germ cell neoplasia in situ]] - left of image. (WC)
| Abbrev    = PLAP
| Synonyms  =
| Similar    = OCT4, OCT3/4
| Clones    =     
| Use        = [[germ cell tumours]]
| Subspecial = [[genitourinary pathology]], [[gynecologic pathology]] 
| Pattern    = membranous
| Positive  = [[germ cell neoplasia in situ]] (previously ITGCN), [[seminoma]], [[embryonal carcinoma]]
| Negative  = normal testis, Sertoli cells only
| Other      =
}}
'''Placental alkaline phosphatase''', abbreviated '''PLAP''', is a common [[immunostain]] used for assessing suspected [[germ cell tumours]].


It has largely been replaced by OCT4.
It has largely been replaced by OCT4.
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==Negative==
==Negative==
*Normal [[testis]].<ref name=pmid9104938>{{Cite journal  | last1 = Hawkins | first1 = E. | last2 = Heifetz | first2 = SA. | last3 = Giller | first3 = R. | last4 = Cushing | first4 = B. | title = The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group. | journal = Hum Pathol | volume = 28 | issue = 4 | pages = 404-10 | month = Apr | year = 1997 | doi =  | PMID = 9104938 }}</ref>
*Normal [[testis]].<ref name=pmid9104938>{{Cite journal  | last1 = Hawkins | first1 = E. | last2 = Heifetz | first2 = SA. | last3 = Giller | first3 = R. | last4 = Cushing | first4 = B. | title = The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group. | journal = Hum Pathol | volume = 28 | issue = 4 | pages = 404-10 | month = Apr | year = 1997 | doi =  | PMID = 9104938 }}</ref>
*Sertoli cells only.


==Positive==
==Positive==
*[[Intratubular germ cell neoplasia]].<ref name=pmid12598912>{{Cite journal  | last1 = Schreiber | first1 = L. | last2 = Lifschitz-Mercer | first2 = B. | last3 = Paz | first3 = G. | last4 = Yavetz | first4 = H. | last5 = Elliott | first5 = DJ. | last6 = Kula | first6 = K. | last7 = Slowikowska-Hilczer | first7 = J. | last8 = Maymon | first8 = BB. | title = Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis. | journal = Int J Surg Pathol | volume = 11 | issue = 1 | pages = 17-20 | month = Jan | year = 2003 | doi =  | PMID = 12598912 }}</ref>
*[[Germ cell neoplasia in situ]] (intratubular germ cell neoplasia).<ref name=pmid12598912>{{Cite journal  | last1 = Schreiber | first1 = L. | last2 = Lifschitz-Mercer | first2 = B. | last3 = Paz | first3 = G. | last4 = Yavetz | first4 = H. | last5 = Elliott | first5 = DJ. | last6 = Kula | first6 = K. | last7 = Slowikowska-Hilczer | first7 = J. | last8 = Maymon | first8 = BB. | title = Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis. | journal = Int J Surg Pathol | volume = 11 | issue = 1 | pages = 17-20 | month = Jan | year = 2003 | doi =  | PMID = 12598912 }}</ref>
*[[Seminoma]].
*[[Seminoma]].
*[[Embryonal carcinoma]].
*[[Embryonal carcinoma]].
===Images===
<gallery>
Image: ITGCN and Sertoli cells only - PLAP -- intermed mag.jpg | [[Germ cell neoplasia in situ]] (GCNIS) & Sertoli cells only (SCO) - intermed. mag.
Image: ITGCN and Sertoli cells only - PLAP -- high mag.jpg | GCNIS & SCO - high mag.
Image: ITGCN and Sertoli cells only - PLAP -- very high mag.jpg | GCNIS & SCO - very high mag.
</gallery>


==See also==
==See also==

Latest revision as of 19:06, 8 January 2017

Placental alkaline phosphatase
Immunostain in short

PLAP in germ cell neoplasia in situ - left of image. (WC)
Abbreviation PLAP
Similar stains OCT4, OCT3/4
Use germ cell tumours
Subspeciality genitourinary pathology, gynecologic pathology
Normal staining pattern membranous
Positive germ cell neoplasia in situ (previously ITGCN), seminoma, embryonal carcinoma
Negative normal testis, Sertoli cells only

Placental alkaline phosphatase, abbreviated PLAP, is a common immunostain used for assessing suspected germ cell tumours.

It has largely been replaced by OCT4.

Negative

Positive

Images

See also

References

  1. Hawkins, E.; Heifetz, SA.; Giller, R.; Cushing, B. (Apr 1997). "The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group.". Hum Pathol 28 (4): 404-10. PMID 9104938.
  2. Schreiber, L.; Lifschitz-Mercer, B.; Paz, G.; Yavetz, H.; Elliott, DJ.; Kula, K.; Slowikowska-Hilczer, J.; Maymon, BB. (Jan 2003). "Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis.". Int J Surg Pathol 11 (1): 17-20. PMID 12598912.