Difference between revisions of "Placental alkaline phosphatase"

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*[[Seminoma]].
*[[Seminoma]].
*[[Embryonal carcinoma]].
*[[Embryonal carcinoma]].
===Images===
<gallery>
Image: ITGCN and Sertoli cells only - PLAP -- intermed mag.jpg | [[Germ cell neoplasia in situ]] (GCNIS) & [[Sertoli cells only]] (SCO) - intermed. mag.
Image: ITGCN and Sertoli cells only - PLAP -- high mag.jpg | GCNIS & SCO - high mag.
Image: ITGCN and Sertoli cells only - PLAP -- very high mag.jpg | GCNIS & SCO - very high mag.
</gallery>


==See also==
==See also==

Revision as of 19:05, 8 January 2017

Placental alkaline phosphatase
Immunostain in short

PLAP in germ cell neoplasia in situ - left of image. (WC)
Abbreviation PLAP
Similar stains OCT4, OCT3/4
Use germ cell tumours
Subspeciality genitourinary pathology, gynecologic pathology
Normal staining pattern membranous
Positive germ cell neoplasia in situ (previously ITGCN), seminoma, embryonal carcinoma

Placental alkaline phosphatase, abbreviated PLAP, is a common immunostain used for assessing suspected germ cell tumours.

It has largely been replaced by OCT4.

Negative

Positive

Images

See also

References

  1. Hawkins, E.; Heifetz, SA.; Giller, R.; Cushing, B. (Apr 1997). "The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group.". Hum Pathol 28 (4): 404-10. PMID 9104938.
  2. Schreiber, L.; Lifschitz-Mercer, B.; Paz, G.; Yavetz, H.; Elliott, DJ.; Kula, K.; Slowikowska-Hilczer, J.; Maymon, BB. (Jan 2003). "Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis.". Int J Surg Pathol 11 (1): 17-20. PMID 12598912.