Difference between revisions of "Nuclear pleomorphism"

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'''Nuclear pleomorphism''' is a common finding in [[cancer|malignant lesions]].  
[[Image:Glioblastoma_with_extreme_nuclear_enlargement_-_very_high_mag.jpg|thumb|350px|Extreme nuclear pleomorphism in a case of [[glioblastoma]].]]
 
[[Image:Pleomorphic undifferentiated sarcoma - very high mag.jpg|thumb|350px|right|Severe nuclear pleomorphism is a case of [[pleomorphic undifferentiated sarcoma]]. [[H&E stain]].]]
'''Anisonucleosis''' is often used as a synonym for ''nuclear pleomorphism''; ''iso-'' means ''equal'' or ''identical'',<ref>URL: [http://dictionary.reference.com/browse/iso-?s=ts http://dictionary.reference.com/browse/iso-?s=ts]. Accessed on: 26 September 2013.</ref> and ''an-'' means ''not''.<ref>URL: [http://dictionary.reference.com/browse/an-?s=t http://dictionary.reference.com/browse/an-?s=t]. Accessed on: 26 September 2013.</ref>
[[Image:Mucinous lung adenocarcinoma and airway - alt -- high mag.jpg|thumb|350px|right|Some forms of cancer have no or minimal nuclear pleomorphism; mucinous [[adenocarcinoma of the lung]] (left of image) looks similar to (benign) gastric foveolar epithelium and in this image is juxtaposed with benign ciliated epithelium (right of image). [[H&E stain]].]]
'''Nuclear pleomorphism''' is a common finding in [[cancer|malignant lesions]]. '''Anisonucleosis''' is often used as a synonym for ''nuclear pleomorphism''; ''iso-'' means ''equal'' or ''identical'',<ref>URL: [http://dictionary.reference.com/browse/iso-?s=ts http://dictionary.reference.com/browse/iso-?s=ts]. Accessed on: 26 September 2013.</ref> and ''an-'' means ''not''.<ref>URL: [http://dictionary.reference.com/browse/an-?s=t http://dictionary.reference.com/browse/an-?s=t]. Accessed on: 26 September 2013.</ref>


==Definition==
Nuclear pleomorphism is the marked variation of:<ref name=pmid21849255>{{Cite journal  | last1 = Rashid | first1 = F. | last2 = Ul Haque | first2 = A. | title = Frequencies of different nuclear morphological features in prostate adenocarcinoma. | journal = Ann Diagn Pathol | volume = 15 | issue = 6 | pages = 414-21 | month = Dec | year = 2011 | doi = 10.1016/j.anndiagpath.2011.06.002 | PMID = 21849255 }}</ref>
Nuclear pleomorphism is the marked variation of:<ref name=pmid21849255>{{Cite journal  | last1 = Rashid | first1 = F. | last2 = Ul Haque | first2 = A. | title = Frequencies of different nuclear morphological features in prostate adenocarcinoma. | journal = Ann Diagn Pathol | volume = 15 | issue = 6 | pages = 414-21 | month = Dec | year = 2011 | doi = 10.1016/j.anndiagpath.2011.06.002 | PMID = 21849255 }}</ref>
#Nuclear size.
#Nuclear size.
#Nuclear shape.
#Nuclear shape.
#Nuclear staining (esp. hyperchromasia).
#Nuclear staining (especially with hyperchromasia).


Memory device '''3 S''': '''s'''ize, '''s'''hape, '''s'''taining.
Memory device '''3 S''': '''s'''ize, '''s'''hape, '''s'''taining.
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*[[NC ratio]].
*[[NC ratio]].
*[[Pleomorphic tumours]].
*[[Pleomorphic tumours]].
*[[Nuclear atypia]].


==References==
==References==

Latest revision as of 03:05, 16 June 2016

Extreme nuclear pleomorphism in a case of glioblastoma.
Severe nuclear pleomorphism is a case of pleomorphic undifferentiated sarcoma. H&E stain.
Some forms of cancer have no or minimal nuclear pleomorphism; mucinous adenocarcinoma of the lung (left of image) looks similar to (benign) gastric foveolar epithelium and in this image is juxtaposed with benign ciliated epithelium (right of image). H&E stain.

Nuclear pleomorphism is a common finding in malignant lesions. Anisonucleosis is often used as a synonym for nuclear pleomorphism; iso- means equal or identical,[1] and an- means not.[2]

Definition

Nuclear pleomorphism is the marked variation of:[3]

  1. Nuclear size.
  2. Nuclear shape.
  3. Nuclear staining (especially with hyperchromasia).

Memory device 3 S: size, shape, staining.

Images

See also

References

  1. URL: http://dictionary.reference.com/browse/iso-?s=ts. Accessed on: 26 September 2013.
  2. URL: http://dictionary.reference.com/browse/an-?s=t. Accessed on: 26 September 2013.
  3. Rashid, F.; Ul Haque, A. (Dec 2011). "Frequencies of different nuclear morphological features in prostate adenocarcinoma.". Ann Diagn Pathol 15 (6): 414-21. doi:10.1016/j.anndiagpath.2011.06.002. PMID 21849255.