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Difference between revisions of "Trophoblast"
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====Images==== | ====Images==== | ||
<gallery> | <gallery> | ||
Image: | Image: Chorionic villi - low mag.jpg | Chorionic villi - low mag. (WC) | ||
Image: | Image: Chorionic villi - intermed mag.jpg | Chorionic villi - intermed. mag. (WC) | ||
Image: Chorionic villi - high mag.jpg | Chorionic villi - high mag. (WC) | |||
Image: Chorionic villi - very high mag.jpg | Chorionic villi - very high mag. - image has numerous annotations. (WC) | |||
</gallery> | </gallery> | ||
www: | www: | ||
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**Eosinophilic vacuolated cytoplasm (contains hCG). | **Eosinophilic vacuolated cytoplasm (contains hCG). | ||
**Closest to mom - covers cytotrophoblast.<ref>[http://upload.wikimedia.org/wikipedia/commons/4/45/Gray37.png http://upload.wikimedia.org/wikipedia/commons/4/45/Gray37.png]</ref> | **Closest to mom - covers cytotrophoblast.<ref>[http://upload.wikimedia.org/wikipedia/commons/4/45/Gray37.png http://upload.wikimedia.org/wikipedia/commons/4/45/Gray37.png]</ref> | ||
Note: | |||
*Syncytiotrophoblasts arise from cytotrophoblasts.<ref name=pmid24595308>{{Cite journal | last1 = Díaz | first1 = P. | last2 = Wood | first2 = AM. | last3 = Sibley | first3 = CP. | last4 = Greenwood | first4 = SL. | title = Intermediate conductance Ca2+-activated K+ channels modulate human placental trophoblast syncytialization. | journal = PLoS One | volume = 9 | issue = 3 | pages = e90961 | month = | year = 2014 | doi = 10.1371/journal.pone.0090961 | PMID = 24595308 }}</ref> | |||
====Images==== | |||
<gallery> | |||
Image: Seminoma with syncytiotrophoblasts -- low mag.jpg | Syncytiotrophoblasts in seminoma - low mag. | |||
Image: Seminoma with syncytiotrophoblasts -- intermed mag.jpg | Syncytiotrophoblasts in seminoma - intermed. mag. | |||
Image: Seminoma with syncytiotrophoblasts -- high mag.jpg | Syncytiotrophoblasts in seminoma - high mag. | |||
Image: Seminoma with syncytiotrophoblasts -- very high mag.jpg | Syncytiotrophoblasts in seminoma - very high mag. | |||
</gallery> | |||
===Cytotrophoblasts=== | ===Cytotrophoblasts=== | ||
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==Age of villi== | ==Age of villi== | ||
===Young villi=== | ===Young villi=== | ||
* | *Few [[blood vessel]]s, central location. | ||
* | *Few syncytial knots. | ||
===Old villi=== | ===Old villi=== | ||
*Blood vessels present and at the periphery of | *Blood vessels present and at the periphery of villi. | ||
*Syncytial knots. | *Syncytial knots. | ||
| Line 128: | Line 141: | ||
| '''Other''' | | '''Other''' | ||
|- | |- | ||
| First trimester (<13 weeks<ref>{{Cite journal | last1 = Haggerty | first1 = CL. | last2 = Seifert | first2 = ME. | last3 = Tang | first3 = G. | last4 = Olsen | first4 = J. | last5 = Bass | first5 = DC. | last6 = Karumanchi | first6 = SA. | last7 = Ness | first7 = RB. | title = Second trimester anti-angiogenic proteins and preeclampsia. | journal = Pregnancy Hypertens | volume = 2 | issue = 2 | pages = 158-163 | month = Apr | year = 2012 | doi = 10.1016/j.preghy.2012.01.005 | PMID = 22712058 }}</ref>) | | First trimester (<13 weeks<ref name=pmid22712058>{{Cite journal | last1 = Haggerty | first1 = CL. | last2 = Seifert | first2 = ME. | last3 = Tang | first3 = G. | last4 = Olsen | first4 = J. | last5 = Bass | first5 = DC. | last6 = Karumanchi | first6 = SA. | last7 = Ness | first7 = RB. | title = Second trimester anti-angiogenic proteins and preeclampsia. | journal = Pregnancy Hypertens | volume = 2 | issue = 2 | pages = 158-163 | month = Apr | year = 2012 | doi = 10.1016/j.preghy.2012.01.005 | PMID = 22712058 }}</ref>) | ||
| present | | present | ||
| both can be identified | | both can be identified | ||
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**May be multi-nucleated. | **May be multi-nucleated. | ||
Images: | ====Images==== | ||
<gallery> | |||
Image:Intermediate trophoblast - intermed mag.jpg | IT - intermed. mag. (WC/Nephron) | |||
Image:Intermediate trophoblast 2 - intermed mag.jpg | IT - intermed. mag. (WC/Nephron) | |||
Image:Intermediate_trophoblast_-_high_mag.jpg | IT - high mag. (WC/Nephron) | |||
Image:Intermediate_trophoblast_-_lmwk_-_high_mag.jpg | IT - LMWK - high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://pathology2.jhu.edu/trophoblast/introduction.cfm IT - high mag. (jhu.edu)]. | *[http://pathology2.jhu.edu/trophoblast/introduction.cfm IT - high mag. (jhu.edu)]. | ||
====IHC==== | ====IHC==== | ||
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*beta-hCG -ve. | *beta-hCG -ve. | ||
*Keratin +ve. | *Keratin +ve. | ||
*EMA +ve in 2nd & 3rd trimester. | **[[CK7]] +ve.<ref name=pmid19069710>{{Cite journal | last1 = Trenkić | first1 = M. | last2 = Basić | first2 = M. | last3 = Milentijević | first3 = M. | last4 = Petrović | first4 = A. | last5 = Zivković | first5 = V. | last6 = Lazarević | first6 = V. | title = Immunohistohemical evidences of pregnancy in uterine curettage tissue by the use of a double immunocytochemical staining technique using cytokeratin 7 and vimentin antibodies. | journal = Vojnosanit Pregl | volume = 65 | issue = 11 | pages = 810-3 | month = Nov | year = 2008 | doi = | PMID = 19069710 }} | ||
</ref> | |||
*[[EMA]] +ve in 2nd & 3rd trimester. | |||
*CD146 +ve.<ref>URL: [http://www.epitomics.com/diagnostics/product/5618 http://www.epitomics.com/diagnostics/product/5618]. Accessed on: 14 August 2011.</ref> | *CD146 +ve.<ref>URL: [http://www.epitomics.com/diagnostics/product/5618 http://www.epitomics.com/diagnostics/product/5618]. Accessed on: 14 August 2011.</ref> | ||