Difference between revisions of "Thecoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Thecoma_high_mag.jpg
| Width      =
| Caption    = Thecoma. [[H&E stain]].
| Synonyms  =
| Micro      = bland oval or spindled nuclei, abundant cytoplasm that is pale and vaculolated
| Subtypes  =
| LMDDx      = [[ovarian fibroma]], fibroma-thecoma
| Stains    =
| IHC        = alpha-inhibin +ve
| EM        =
| Molecular  =
| IF        =
| Gross      = solid yellow mass, usually well-circumscribed
| Grossing  =
| Site      = [[ovary]] - see ''[[ovarian tumours]]''
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = other [[ovarian tumours]]
| Tx        =
}}
'''Thecoma''' is an [[ovarian tumour|ovarian]] [[Sex cord-stromal tumours|sex-cord stromal tumour]].
'''Thecoma''' is an [[ovarian tumour|ovarian]] [[Sex cord-stromal tumours|sex-cord stromal tumour]].


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*Nuclei with oval to spindle morphology.
*Nuclei with oval to spindle morphology.
*Abundant cytoplasm that is pale, vaculolated -- '''key feature'''.
*Abundant cytoplasm that is pale, vaculolated -- '''key feature'''.
DDx:
*[[Ovarian fibroma]].
*[[Leiomyoma]] - rare.
*Other [[sex cord-stromal tumour]]s.


===Images===
===Images===

Latest revision as of 16:10, 29 November 2015

Thecoma
Diagnosis in short

Thecoma. H&E stain.

LM bland oval or spindled nuclei, abundant cytoplasm that is pale and vaculolated
LM DDx ovarian fibroma, fibroma-thecoma
IHC alpha-inhibin +ve
Gross solid yellow mass, usually well-circumscribed
Site ovary - see ovarian tumours

Prevalence uncommon
Prognosis benign
Clin. DDx other ovarian tumours

Thecoma is an ovarian sex-cord stromal tumour.

General

  • Associated with compression & atrophy of ovarian cortex, thought to arise from medulla.[1]
  • Approximately 50% have symptoms related to estrogen secretion.[2]
    • May also be viralizing.

Gross

Features:

  • Solid yellow mass, usually well-circumscribed.[3]

DDx:

Microscopic

Features:[2]

  • Nuclei with oval to spindle morphology.
  • Abundant cytoplasm that is pale, vaculolated -- key feature.

DDx:

Images

IHC

  • Alpha-inhibin +ve (90%+).[2]

See also

References

  1. Nocito, AL.; Sarancone, S.; Bacchi, C.; Tellez, T. (Feb 2008). "Ovarian thecoma: clinicopathological analysis of 50 cases.". Ann Diagn Pathol 12 (1): 12-6. doi:10.1016/j.anndiagpath.2007.01.011. PMID 18164409.
  2. 2.0 2.1 2.2 Roth, LM. (Jul 2006). "Recent advances in the pathology and classification of ovarian sex cord-stromal tumors.". Int J Gynecol Pathol 25 (3): 199-215. doi:10.1097/01.pgp.0000192271.22289.e6. PMID 16810055.
  3. 3.0 3.1 Rose, Alan G. (2008). Atlas of Gross Pathology with Histologic Correlation (1st ed.). Cambridge University Press. pp. 398. ISBN 978-0521868792.