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Difference between revisions of "Renal leiomyoma"
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'''Renal leiomyoma''', also '''leiomyoma of the [[kidney]], is a very rare benign [[kidney tumour]]. | '''Renal leiomyoma''', also '''leiomyoma of the [[kidney]]''', is a very rare benign [[kidney tumour]]. | ||
==General== | ==General== | ||
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DDx: | DDx: | ||
*[[Angiomyolipoma]]. | *[[Angiomyolipoma]] - typically contain adipose tissue. | ||
*[[Leiomyosarcoma]]<ref name=pmid25526990>{{Cite journal | last1 = Fu | first1 = L. | last2 = Humphrey | first2 = PA. | last3 = Adeniran | first3 = AJ. | title = Renal Leiomyoma. | journal = J Urol | volume = | issue = | pages = | month = Dec | year = 2014 | doi = 10.1016/j.juro.2014.12.083 | PMID = 25526990 }}</ref> - typically have at least some of the following: nuclear atypia, mitosis, necrosis. | |||
==IHC== | ==IHC== | ||
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*Desmin +ve. | *Desmin +ve. | ||
*ER and PR +ve (6 of 9 cases:<ref name=pmid25517956/>). | *ER and PR +ve (6 of 9 cases:<ref name=pmid25517956/>). | ||
==Sign out== | |||
<pre> | |||
Mass Lesion, Right Kidney, Core Biopsy: | |||
- Benign leiomyoma with hyalinization and without atypia, see comment. | |||
- Renal parenchyma within normal limits present. | |||
- NEGATIVE for malignancy. | |||
Comment: | |||
The tumour stains as follows: | |||
POSITIVE: desmin, SMA, ER, PR. | |||
NEGATIVE: HMB-45. | |||
Proliferation (Ki-67): 0%. | |||
The tumour histology and immunoprofile is that of a leiomyoma. Renal leiomyomas are very rare lesions; a large contemporary series has only 9 cases. [1] | |||
Correlation with radiology is suggested. | |||
1. Am J Surg Pathol. 2015 Mar;39(3):349-56. | |||
</pre> | |||
===Micro=== | |||
The sections show tumour with a fascicular architecture and hyalinization. No adipose tissue is seen. Necrosis is not identified. Nuclear atypia is not seen. Mitotic activity is not readily apparent. Benign unremarkable renal parenchyma is present. | |||
==See also== | ==See also== | ||
*[[Leiomyoma]]. | *[[Leiomyoma]]. | ||
*[[Kidney tumours]]. | |||
==References== | ==References== | ||