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Difference between revisions of "Non-specific interstitial pneumonia"
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Non-specific interstitial pneumonia (view source)
Revision as of 18:53, 17 March 2015
, 18:53, 17 March 2015→Microscopic: +images
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Non-specfic_interstitial_pneumonia_(NSIP),_cellular_variant.jpg | |||
| Width = | |||
| Caption = NSIP. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = diffuse fibrosis (uniform fibrosis (unlike [[UIP]]), +/-''linear fibrosis'' (fibrosis that follows alveolar walls + no architectural distortion), +/-lymphoid nodules (assoc. with collagen vascular disease), +/-focal [[organizing pneumonia]] | |||
| Subtypes = idiopathic NSIP, NSIP due to an underlying cause | |||
| LMDDx = [[organizing pneumonia]], [[collagen vascular disease]], drug reaction, [[hypersensitivity pneumonitis]], [[lymphocytic interstitial pneumonia]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lung]] - see ''[[diffuse lung diseases]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = cough | |||
| Symptoms = dyspnea | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = lower lung zone fibrosis, patchy ground glass, no honeycombing | |||
| Endoscopy = | |||
| Prognosis = good | |||
| Other = | |||
| ClinDDx = | |||
| Tx = corticosteroids (?) | |||
}} | |||
'''Non-specific interstitial pneumonia''', abbreviated '''NSIP''', is an uncommon type of [[diffuse lung disease]]. | '''Non-specific interstitial pneumonia''', abbreviated '''NSIP''', is an uncommon type of [[diffuse lung disease]]. | ||
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*[[Connective tissue disease]].<ref name=pmid21437858>{{cite journal |author=Hauber HP, Bittmann I, Kirsten D |title=[Non-specific interstitial pneumonia (NSIP)] |language=German |journal=Pneumologie |volume=65 |issue=8 |pages=477–83 |year=2011 |month=August |pmid=21437858 |doi=10.1055/s-0030-1256284 |url=}}</ref> | *[[Connective tissue disease]].<ref name=pmid21437858>{{cite journal |author=Hauber HP, Bittmann I, Kirsten D |title=[Non-specific interstitial pneumonia (NSIP)] |language=German |journal=Pneumologie |volume=65 |issue=8 |pages=477–83 |year=2011 |month=August |pmid=21437858 |doi=10.1055/s-0030-1256284 |url=}}</ref> | ||
*[[Rheumatoid arthritis]]. | *[[Rheumatoid arthritis]]. | ||
Note: | |||
*If no underlying cause is present it is known as ''idiopathic NSIP''. | |||
Clinical features (typical) of the idiopathic form:<ref name=pmid20178304>{{cite journal |author=Romagnoli M, Poletti V |title=[Update on non-specific interstitial pneumonia: a pattern, a clinical entity or different phenotypes? Surgical or bronchoscopic diagnosis?] |language=Italian |journal=Recenti Prog Med |volume=100 |issue=12 |pages=531–4 |year=2009 |month=December |pmid=20178304 |doi= |url=}}</ref> | |||
*Middle-aged, never-smoker women. | |||
*[[Dyspnea]]. | |||
*Cough. | |||
*Ground glass on HRCT. | |||
*Very good prognosis. | |||
==Gross/Radiology== | ==Gross/Radiology== | ||
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DDx: | DDx: | ||
*Collagen vascular disease. | *[[Collagen vascular disease]]. | ||
*Drug reaction. | *[[Drug reaction]]. | ||
*[[Hypersensitivity pneumonitis]] (extrinic allergic alveolitis). | *[[Hypersensitivity pneumonitis]] (extrinic allergic alveolitis). | ||
*[[Lymphocytic interstitial pneumonia]] (LIP) - much more inflammation. | *[[Lymphocytic interstitial pneumonia]] (LIP) - much more inflammation. | ||
*[[Organizing pneumonia]]. | |||
===Images=== | |||
<gallery> | |||
Image: Non-specfic_interstitial_pneumonia_(NSIP),_cellular_variant.jpg | NSIP - cellular. (WC/Rosen) | |||
Image: Non-specfic_interstitial_pneumonia_(NSIP),_cellular_variant_2.jpg | NSIP - cellular. (WC/Rosen) | |||
Image: Non-specfic interstitial pneumonia (NSIP), fibrosing variant.jpg | NSIP - fibrosing. (WC/Rosen) | |||
Image: Non-specfic interstitial pneumonia (NSIP), fibrosing variant_2.jpg | NSIP - fibrosing. (WC/Rosen) | |||
</gallery> | |||
==See also== | ==See also== | ||