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Difference between revisions of "Poorly differentiated thyroid carcinoma"
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Poorly differentiated thyroid carcinoma (view source)
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'''Poorly differentiated thyroid carcinoma''', abbreviated '''PDTC''', is a distinct type of thyroid carcinoma recognized in the 2004 WHO classification of thyroid tumours.<ref name=pmid21969055>{{Cite journal | last1 = Tallini | first1 = G. | title = Poorly differentiated thyroid carcinoma. Are we there yet? | journal = Endocr Pathol | volume = 22 | issue = 4 | pages = 190-4 | month = Dec | year = 2011 | doi = 10.1007/s12022-011-9176-5 | PMID = 21969055 }}</ref><ref name=pmid19960273>{{Cite journal | last1 = Volante | first1 = M. | last2 = Papotti | first2 = M. | title = Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours. | journal = Endocr Pathol | volume = 21 | issue = 1 | pages = 1-6 | month = Mar | year = 2010 | doi = 10.1007/s12022-009-9100-4 | PMID = 19960273 }}</ref> | '''Poorly differentiated thyroid carcinoma''', abbreviated '''PDTC''', is a distinct type of thyroid carcinoma that is recognized in the 2004 WHO classification of thyroid tumours.<ref name=pmid21969055>{{Cite journal | last1 = Tallini | first1 = G. | title = Poorly differentiated thyroid carcinoma. Are we there yet? | journal = Endocr Pathol | volume = 22 | issue = 4 | pages = 190-4 | month = Dec | year = 2011 | doi = 10.1007/s12022-011-9176-5 | PMID = 21969055 }}</ref><ref name=pmid19960273>{{Cite journal | last1 = Volante | first1 = M. | last2 = Papotti | first2 = M. | title = Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours. | journal = Endocr Pathol | volume = 21 | issue = 1 | pages = 1-6 | month = Mar | year = 2010 | doi = 10.1007/s12022-009-9100-4 | PMID = 19960273 }}</ref> It does not refer to high grade thyroid tumours.<ref name=pmid21969055/> | ||
==General== | |||
*Prognosis between that of [[papillary thyroid carcinoma]] and [[anaplastic thyroid carcinoma]].<ref name=pmid20562850>{{Cite journal | last1 = Asioli | first1 = S. | last2 = Erickson | first2 = LA. | last3 = Righi | first3 = A. | last4 = Jin | first4 = L. | last5 = Volante | first5 = M. | last6 = Jenkins | first6 = S. | last7 = Papotti | first7 = M. | last8 = Bussolati | first8 = G. | last9 = Lloyd | first9 = RV. | title = Poorly differentiated carcinoma of the thyroid: validation of the Turin proposal and analysis of IMP3 expression. | journal = Mod Pathol | volume = 23 | issue = 9 | pages = 1269-78 | month = Sep | year = 2010 | doi = 10.1038/modpathol.2010.117 | PMID = 20562850 }}</ref> | |||
==Microscopic== | |||
Required features - so called ''Turin criteria'':<ref name=pmid17667551>{{Cite journal | last1 = Volante | first1 = M. | last2 = Collini | first2 = P. | last3 = Nikiforov | first3 = YE. | last4 = Sakamoto | first4 = A. | last5 = Kakudo | first5 = K. | last6 = Katoh | first6 = R. | last7 = Lloyd | first7 = RV. | last8 = LiVolsi | first8 = VA. | last9 = Papotti | first9 = M. | title = Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach. | journal = Am J Surg Pathol | volume = 31 | issue = 8 | pages = 1256-64 | month = Aug | year = 2007 | doi = 10.1097/PAS.0b013e3180309e6a | PMID = 17667551 }}</ref> | |||
# Solid, trabecular or insular pattern of growth. | |||
# Absence of nuclear features for (conventional) [[papillary thyroid carcinoma]]. | |||
# One of the following: | |||
## Convoluted nuclei. | |||
## >= 3 mitoses/10 [[HPF]]. | |||
## Tumour necrosis. | |||
==See also== | ==See also== | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Thyroid gland]] | |||