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Difference between revisions of "Chondrosarcoma"
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→Clear cell chondrosarcoma
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====Clear cell chondrosarcoma==== | ====Clear cell chondrosarcoma==== | ||
*Rare variant of chondrosarcoma (1.6%–5.4% of all chondrosarcomas) | *Rare variant of chondrosarcoma (1.6%–5.4% of all chondrosarcomas) | ||
* | *Usually a low-grade malignant tumour<ref>{{Cite journal | last1 = Corradi | first1 = D. | last2 = Bacchini | first2 = P. | last3 = Campanini | first3 = N. | last4 = Bertoni | first4 = F. | title = Aggressive clear cell chondrosarcomas: do distinctive characteristics exist?: a report of 4 cases. | journal = Arch Pathol Lab Med | volume = 130 | issue = 11 | pages = 1673-9 | month = Nov | year = 2006 | doi = 10.1043/1543-2165(2006)130[1673:ACCCDD]2.0.CO;2 | PMID = 17076530 }}</ref> | ||
*Younger age than conventional chondrosarcoma | *Younger age than conventional chondrosarcoma | ||
* | *Teens to 40s; more common in males | ||
*Epiphyses of long tubular bones; proximal femur or humerus | *Epiphyses of long tubular bones; proximal femur or humerus | ||
* | *Rarely head and neck <ref>{{Cite journal | last1 = Mokhtari | first1 = S. | last2 = Mirafsharieh | first2 = A. | title = Clear cell chondrosarcoma of the head and neck. | journal = Head Neck Oncol | volume = 4 | issue = | pages = 13 | month = | year = 2012 | doi = 10.1186/1758-3284-4-13 | PMID = 22520362 }}</ref> | ||
*Malignant counterpart of chondroblastoma? | |||
Microscopic findings | Microscopic findings | ||
*Lobules of | *Lobules of uniform to polymorphic densely-packed large cells | ||
*Clear | *Well defined pushing borders | ||
*Clear to intensively acidophilic granular cytoplasm cytoplasm with vacuoles | |||
*Central nuclei with occasional prominent nucleoli | *Central nuclei with occasional prominent nucleoli | ||
* | *Low mitotic rate | ||
* | *Clear cell areas lack production of hyaline chondroid matrix | ||
May have secondary aneurysmal bone cyst changes | *Areas with osteoclast-type giant cells mixed with small trabeculae of reactive bone | ||
*May contain conventional low-grade chondrosarcoma | |||
*May have secondary aneurysmal bone cyst changes | |||
<gallery> | <gallery> | ||
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DDX: | DDX: | ||
*Chondroblastoma | *Chondroblastoma | ||
*Giant cell tumour of bone | |||
*Osteoblastic tumours | |||
*Metastatic clear cell renal cell carcinoma | |||
====Extraskeletal myxoid chondrosarcoma==== | ====Extraskeletal myxoid chondrosarcoma==== | ||