Difference between revisions of "Smooth muscle tumour of uncertain malignant potential"

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#redirect [[Uterine_tumours#Smooth_muscle_tumour_of_uncertain_malignant_potential]]
'''Smooth muscle tumour of uncertain malignant potential''', abbreviated '''STUMP''' is smooth muscle lesion in which the behaviour (benign vs. malignant) cannot be ascertained with certainty.


==General==
*Like ''[[ASAP]]'' and ''[[ASCUS]]'' - a [[waffle diagnosis|waffle category]]... when one isn't sure it is a ''leiomyoma'' vs. ''leiomyosarcoma''.
*Clinical behaviour in uterus: usually benign.<ref name=pmid19417585>{{cite journal |author=Ip PP, Cheung AN, Clement PB |title=Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases |journal=Am. J. Surg. Pathol. |volume=33 |issue=7 |pages=992–1005 |year=2009 |month=July |pmid=19417585 |doi=10.1097/PAS.0b013e3181a02d1c |url=}}</ref>
*Can be subclassified into four groups - as per Stanford.
*May be seen in the [[prostate gland]].<ref name=pmid21572264>{{Cite journal  | last1 = Nagar | first1 = M. | last2 = Epstein | first2 = JI. | title = Epithelial proliferations in prostatic stromal tumors of uncertain malignant potential (STUMP). | journal = Am J Surg Pathol | volume = 35 | issue = 6 | pages = 898-903 | month = Jun | year = 2011 | doi = 10.1097/PAS.0b013e318214f2f2 | PMID = 21572264 }}</ref>
Management:
*Long-term follow-up.<ref name=pmid19417585/>
==Microscopic==
Features associated with recurrence:<ref name=pmid19417585/>
*Nuclear atypia.
DDx:
*[[Uterine leiomyoma]].
*[[Uterine leiomyosarcoma]].
==IHC==
Features associated with recurrence:<ref name=pmid19417585/>
*p16 +ve.
*p53 +ve.
==See also==
*[[Uterine tumours]].
==References==
{{Reflist|2}}
[[Category:Genitourinary pathology]]
[[Category:Gynecologic pathology]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 02:34, 23 October 2014

Smooth muscle tumour of uncertain malignant potential, abbreviated STUMP is smooth muscle lesion in which the behaviour (benign vs. malignant) cannot be ascertained with certainty.

General

  • Like ASAP and ASCUS - a waffle category... when one isn't sure it is a leiomyoma vs. leiomyosarcoma.
  • Clinical behaviour in uterus: usually benign.[1]
  • Can be subclassified into four groups - as per Stanford.
  • May be seen in the prostate gland.[2]

Management:

  • Long-term follow-up.[1]

Microscopic

Features associated with recurrence:[1]

  • Nuclear atypia.

DDx:

IHC

Features associated with recurrence:[1]

  • p16 +ve.
  • p53 +ve.


See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Ip PP, Cheung AN, Clement PB (July 2009). "Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases". Am. J. Surg. Pathol. 33 (7): 992–1005. doi:10.1097/PAS.0b013e3181a02d1c. PMID 19417585.
  2. ↑ Nagar, M.; Epstein, JI. (Jun 2011). "Epithelial proliferations in prostatic stromal tumors of uncertain malignant potential (STUMP).". Am J Surg Pathol 35 (6): 898-903. doi:10.1097/PAS.0b013e318214f2f2. PMID 21572264.
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