Difference between revisions of "Placental site nodule"

From Libre Pathology
Jump to navigation Jump to search
Line 1: Line 1:
'''Placental site nodule''' is a benign remnant of a [[placenta]]. It is seen on [[endometrium|endometrial]] biopsies and hysterectomy specimens.
'''Placental site nodule''', abbreviated '''PSN''', is a benign remnant of a [[placenta]]. It is seen on [[endometrium|endometrial]] biopsies and hysterectomy specimens.
==General==
==General==
*Benign.
*Benign.

Revision as of 23:14, 20 March 2014

Placental site nodule, abbreviated PSN, is a benign remnant of a placenta. It is seen on endometrial biopsies and hysterectomy specimens.

General

  • Benign.
  • Intermediate trophoblast remnants from a previous gestation.[1]
  • Usually an incidental finding.

Clinical:

  • Usually asymptomatic.
  • Vaginal bleeding. (?)
  • Infertility. (?)

Microscopic

Features:[1]

  • Paucicellular with hyaline material scattered cells.
  • Variable cell population:
    • Small-large cells.
    • Clear to eosinophilic cytoplasm.
    • +/-Multinucleation.

Notes:

  • No mitotic activity.

DDx:

Images

www:

IHC

Features:[1]

  • Inhibin alpha +ve.
  • CK18 +ve.
  • MIB1 low.

Other:

  • p16 -ve.

Sign out

- CONSISTENT WITH MENSTRUAL ENDOMETRIUM (FRAGMENTED ENDOMETRIUM WITH SIMPLE
  GLANDS WITH APOPTOTIC CELLS, ABUNDANT NEUTROPHILS, CONDENSED ENDOMETRIAL STROMA
  (FOCAL) AND BLOOD).
- PLACENTAL SITE NODULE AND DECIDUA.
- NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY.
ENDOMETRIUM, BIOPSY:
- PROLIFERATIVE PHASE ENDOMETRIUM.
- BENIGN PLACENTAL SITE NODULE, SMALL.
- NEGATIVE FOR HYPERPLASIA.

See also

References