Difference between revisions of "Invasive lobular carcinoma"

From Libre Pathology
Jump to navigation Jump to search
Line 77: Line 77:
==See also==
==See also==
*[[Invasive breast cancer]].
*[[Invasive breast cancer]].
*[[Signet ring cell carcinoma]].


==References==
==References==

Revision as of 10:47, 14 February 2014

Invasive lobular carcinoma
Diagnosis in short

Lobular carcinoma. H&E stain.
LM DDx invasive ductal carcinoma of the breast with lobular features, poorly differentiated carcinoma, LCIS
IHC usu. ER and PR +ve, HER2 -ve, CK7 +ve
Site breast - see invasive breast cancer

Syndromes hereditary diffuse gastric cancer syndrome

Prevalence relatively common
Clin. DDx other breast tumours

Invasive lobular carcinoma, abbreviated ILC, is the second most common form of Invasive breast cancer.

It may be referred to as lobular carcinoma; however, this may lead to confusion with lobular carcinoma in situ.

General

  • May be associated with a CDH1 mutation - seen in diffuse type gastric cancer.[1][2]

Microscopic

Features:

  • "Single file" - cell line-up in a row.
    • Cell should not be cohesive -- lymphoma should briefly come to mind.
      • primary lymphoma of the breast exists... but it is extremely rare.
  • NO gland formation.
    • If it forms glands... it is more likely NST.
  • May have signet ring morphology.
  • NO desmoplastic reaction, i.e. the stroma surrounding the tumour cells should look benign and undisturbed.

Note:

  • Commonly have low grade nuclear features.

DDx:

Images

More WC images:

Subclassification

  • Classic lobular carcinoma.
    • Low nuclear grade - NO significant variation of nucleus size.
  • Pleomorphic lobular carcinoma.
    • Significant nuclear atypia.

Note:

  • Some pathologist grade lobular carcinoma like other types and avoid the term "pleomorphic lobular carcinoma."[3]

See also

References