Difference between revisions of "Cholangiocarcinoma"

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Notes:
Notes:
*Biliary stents lead to reactive changes,<ref name=pmid3877438>{{Cite journal  | last1 = Carrasco | first1 = CH | last2 = Wallace | first2 = S | last3 = Charnsangavej | first3 = C | last4 = Richli | first4 = W | last5 = Wright | first5 = KC | last6 = Fanning | first6 = T | last7 = Gianturco | first7 = C | title = Expandable biliary endoprosthesis: an experimental study. | journal = AJR Am J Roentgenol | volume = 145 | issue = 6 | pages = 1279-81 | month = Dec | year = 1985 | doi =  | PMID = 3877438 }}</ref> these can be confused for malignancy.  One must always check whether a biliary stent was in situ at time of biopsy.<ref>STC. 2 October 2009.</ref>
*Biliary stents lead to reactive changes,<ref name=pmid3877438>{{Cite journal  | last1 = Carrasco | first1 = CH | last2 = Wallace | first2 = S | last3 = Charnsangavej | first3 = C | last4 = Richli | first4 = W | last5 = Wright | first5 = KC | last6 = Fanning | first6 = T | last7 = Gianturco | first7 = C | title = Expandable biliary endoprosthesis: an experimental study. | journal = AJR Am J Roentgenol | volume = 145 | issue = 6 | pages = 1279-81 | month = Dec | year = 1985 | doi =  | PMID = 3877438 }}</ref> these can be confused for malignancy.  One must always check whether a biliary stent was in situ at time of biopsy.<ref>STC. 2 October 2009.</ref>
*Usually abundant desmoplasia, ergo hard to get good, i.e. diagnositic, endoluminal brushing specimens.<ref>STC. 6 December 2010.</ref>
*Usually abundant desmoplasia, ergo hard to get good, i.e. diagnositic, endoluminal brushing specimens.<ref name=stc6dec2010>STC. 6 December 2010.</ref>
*May have hyaline inclusions.<ref name=pmid20716803>{{Cite journal  | last1 = Aishima | first1 = S. | last2 = Fujita | first2 = N. | last3 = Mano | first3 = Y. | last4 = Iguchi | first4 = T. | last5 = Taketomi | first5 = A. | last6 = Maehara | first6 = Y. | last7 = Oda | first7 = Y. | last8 = Tsuneyoshi | first8 = M. | title = p62+ Hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease. | journal = Am J Clin Pathol | volume = 134 | issue = 3 | pages = 457-65 | month = Sep | year = 2010 | doi = 10.1309/AJCP53YVVJCNDZIR | PMID = 20716803 | URL = http://ajcp.ascpjournals.org/content/134/3/457.full.pdf }}
*May have hyaline inclusions.<ref name=pmid20716803>{{Cite journal  | last1 = Aishima | first1 = S. | last2 = Fujita | first2 = N. | last3 = Mano | first3 = Y. | last4 = Iguchi | first4 = T. | last5 = Taketomi | first5 = A. | last6 = Maehara | first6 = Y. | last7 = Oda | first7 = Y. | last8 = Tsuneyoshi | first8 = M. | title = p62+ Hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease. | journal = Am J Clin Pathol | volume = 134 | issue = 3 | pages = 457-65 | month = Sep | year = 2010 | doi = 10.1309/AJCP53YVVJCNDZIR | PMID = 20716803 | URL = http://ajcp.ascpjournals.org/content/134/3/457.full.pdf }}
</ref>
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*CK20 +ve/-ve.
*CK20 +ve/-ve.
*HepPar-1 -ve.
*HepPar-1 -ve.
*AFP -ve.<ref>STC. 6 December 2010.</ref>
*AFP -ve.<ref name=stc6dec2010>STC. 6 December 2010.</ref>


ICC vs. HCC:<ref name=pmid19173916>[Evaluation of immunohistochemical markers for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma] Dong H, Cong WL, Zhu ZZ, Wang B, Xian ZH, Yu H. Zhonghua Zhong Liu Za Zhi. 2008 Sep;30(9):702-5. Chinese. PMID 19173916.</ref>
ICC vs. HCC:<ref name=pmid19173916>[Evaluation of immunohistochemical markers for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma] Dong H, Cong WL, Zhu ZZ, Wang B, Xian ZH, Yu H. Zhonghua Zhong Liu Za Zhi. 2008 Sep;30(9):702-5. Chinese. PMID 19173916.</ref>

Revision as of 19:22, 26 January 2014

Cholangiocarcinoma
Diagnosis in short

Cholangiocarcinoma. H&E stain.

Synonyms bile duct carcinoma

LM atypical cuboidal or columnar mucin producing cohesive cells (carcinoma) - usually gland forming (adenocarcinoma), classically with a dense fibrous (desmoplastic) stroma
LM DDx metastatic carcinoma - esp. luminal GI tract, hepatocellular carcinoma
IHC CK7 +ve, CK20 +ve/-ve, CK19 +ve, HepPar-1 -ve, AFP -ve
Site bile ducts (including pancreas, liver - see liver neoplasms)

Associated Dx liver flukes (Clonorchis sinensis, Opisthorchis viverrini), Caroli disease, primary sclerosing cholangitis - esp. in ulcerative colitis
Signs +/-jaundice
Prevalence uncommon
Blood work +/-findings of cholestasis
Prognosis poor
Clin. DDx other liver tumours - hepatocellular carcinoma, metastases
Treatment surgical resection if possible

Cholangiocarcinoma is a malignant tumour that arise from the bile ducts and may been seen in the liver.

It is also known as bile duct carcinoma.[1]

General

  • Malignancy of the biliary tree.
  • May be intrahepatic, i.e. intrahepatic cholangiocarcinoma (abbreviated ICC), or extrahepatic.

Epidemiology

  • Rare - approximately 1/5 the incidence of HCC.[2]
  • More common among asians.

Risks:

Gross

  • Classically one large mass - outline described as cauliflower-like.[7]
    • May have satellite nodules.

Image

Microscopic

Features:[8]

  • Usually an adenocarcinoma, i.e. gland forming with:
    • Cuboidal or columnar mucin producing cells, and
    • A dense fibrous (desmoplastic) stroma.

Notes:

  • Biliary stents lead to reactive changes,[9] these can be confused for malignancy. One must always check whether a biliary stent was in situ at time of biopsy.[10]
  • Usually abundant desmoplasia, ergo hard to get good, i.e. diagnositic, endoluminal brushing specimens.[11]
  • May have hyaline inclusions.[12]

DDx:

Images

www:

IHC

Classic IHC pattern:[13]

  • CK7 +ve.
  • CK20 +ve/-ve.
  • HepPar-1 -ve.
  • AFP -ve.[11]

ICC vs. HCC:[14]

  • ICC: CK19 (92.5%), MUC-1 (73.8%) +ve.
  • HCC: HepPar-1 (85.6%), CD34 (87.8%) +ve.

HCC vs. ICC:[15]

  • TTF-1: ~90-100% +ve (cytoplasmic) in HCC vs. ~10% in cholangiocarcinoma.

Sign out

MASS, PANCREAS, CORE BIOPSY:
- ADENOCARCINOMA, MODERATELY DIFFERENTIATED.

Note:

Micro

The sections show an atypical gland-forming lesion (adenocarcinoma) in a fibrous background. This lesion is separate from the benign pancreatic glands that are present. The atypical glands are unequally spaced. Moderate-to-marked cytologic atypia is present. Mitotic activity is not readily apparent.

See also

References

  1. URL: http://www.cancer.org/cancer/bileductcancer/detailedguide/bile-duct-cancer-what-is-bile-duct-cancer. Access on: 23 May 2013.
  2. Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 608. ISBN 978-0443066573.
  3. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 926. ISBN 0-7216-0187-1.
  4. Park, do H.; Son, HY. (Apr 2008). "Images in clinical medicine. Clonorchis sinensis.". N Engl J Med 358 (16): e18. doi:10.1056/NEJMicm054461. PMID 18420495.
  5. de Martel C, Plummer M, Franceschi S (March 2010). "Cholangiocarcinoma: Descriptive epidemiology and risk factors". Gastroenterol Clin Biol. doi:10.1016/j.gcb.2010.01.008. PMID 20202771.
  6. Ananthakrishnan AN, Saeian K (April 2007). "Caroli's disease: identification and treatment strategy". Curr Gastroenterol Rep 9 (2): 151–5. PMID 17418061.
  7. Nakanishi, Y.; Zen, Y.; Kawakami, H.; Kubota, K.; Itoh, T.; Hirano, S.; Tanaka, E.; Nakanuma, Y. et al. (Jul 2008). "Extrahepatic bile duct carcinoma with extensive intraepithelial spread: a clinicopathological study of 21 cases.". Mod Pathol 21 (7): 807-16. doi:10.1038/modpathol.2008.65. PMID 18425077.
  8. Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 609. ISBN 978-0443066573.
  9. Carrasco, CH; Wallace, S; Charnsangavej, C; Richli, W; Wright, KC; Fanning, T; Gianturco, C (Dec 1985). "Expandable biliary endoprosthesis: an experimental study.". AJR Am J Roentgenol 145 (6): 1279-81. PMID 3877438.
  10. STC. 2 October 2009.
  11. 11.0 11.1 STC. 6 December 2010.
  12. Aishima, S.; Fujita, N.; Mano, Y.; Iguchi, T.; Taketomi, A.; Maehara, Y.; Oda, Y.; Tsuneyoshi, M. (Sep 2010). "p62+ Hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease.". Am J Clin Pathol 134 (3): 457-65. doi:10.1309/AJCP53YVVJCNDZIR. PMID 20716803.
  13. Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 609. ISBN 978-0443066573.
  14. [Evaluation of immunohistochemical markers for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma] Dong H, Cong WL, Zhu ZZ, Wang B, Xian ZH, Yu H. Zhonghua Zhong Liu Za Zhi. 2008 Sep;30(9):702-5. Chinese. PMID 19173916.
  15. Lei JY, Bourne PA, diSant'Agnese PA, Huang J (April 2006). "Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma vs cholangiocarcinoma and metastatic carcinoma of the liver". Am. J. Clin. Pathol. 125 (4): 519–25. doi:10.1309/59TN-EFAL-UL5W-J94M. PMID 16627262.