Difference between revisions of "Metanephric adenoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Metanephric_adenoma_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Metanephric adenoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = small uniform cells with fine chromatin, no apparent [[nucleolus]], and a relatively smooth nuclear membrane; variable architecture - may be sheets or ductal | |||
| Subtypes = | |||
| LMDDx = [[Wilms tumour]], [[papillary renal cell carcinoma]] (type 1) | |||
| Stains = | |||
| IHC = WT-1 +ve, CD57 +ve, AMACR -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[kidney]] - see ''[[kidney tumours]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = usu. adults, occasionally children | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = good, benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Metanephric adenoma''' is a benign tumour of the kidney. | '''Metanephric adenoma''' is a benign tumour of the kidney. | ||
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www: | www: | ||
*[http://www.nature.com/modpathol/journal/v16/n10/fig_tab/3880886f1.html Metanephric adenoma (nature.com)]. | *[http://www.nature.com/modpathol/journal/v16/n10/fig_tab/3880886f1.html Metanephric adenoma (nature.com)]. | ||
==IHC== | ==IHC== | ||
*WT-1 +ve.<ref name=pmid24083046>{{Cite journal | last1 = Watanabe | first1 = S. | last2 = Naganuma | first2 = H. | last3 = Shimizu | first3 = M. | last4 = Ota | first4 = S. | last5 = Murata | first5 = S. | last6 = Nihei | first6 = N. | last7 = Matsushima | first7 = J. | last8 = Mikami | first8 = S. | last9 = Kuroda | first9 = N. | title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. | journal = Case Rep Pathol | volume = 2013 | issue = | pages = 675875 | month = | year = 2013 | doi = 10.1155/2013/675875 | PMID = 24083046 }}</ref> | *WT-1 +ve.<ref name=pmid24083046>{{Cite journal | last1 = Watanabe | first1 = S. | last2 = Naganuma | first2 = H. | last3 = Shimizu | first3 = M. | last4 = Ota | first4 = S. | last5 = Murata | first5 = S. | last6 = Nihei | first6 = N. | last7 = Matsushima | first7 = J. | last8 = Mikami | first8 = S. | last9 = Kuroda | first9 = N. | title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. | journal = Case Rep Pathol | volume = 2013 | issue = | pages = 675875 | month = | year = 2013 | doi = 10.1155/2013/675875 | PMID = 24083046 }}</ref> | ||
Revision as of 03:17, 22 December 2013
| Metanephric adenoma | |
|---|---|
| Diagnosis in short | |
 Metanephric adenoma. H&E stain. | |
|
| |
| LM | small uniform cells with fine chromatin, no apparent nucleolus, and a relatively smooth nuclear membrane; variable architecture - may be sheets or ductal |
| LM DDx | Wilms tumour, papillary renal cell carcinoma (type 1) |
| IHC | WT-1 +ve, CD57 +ve, AMACR -ve |
| Site | kidney - see kidney tumours |
|
| |
| Clinical history | usu. adults, occasionally children |
| Prevalence | uncommon |
| Prognosis | good, benign |
Metanephric adenoma is a benign tumour of the kidney.
It should not be confused mesonephric adenoma, another term for nephrogenic adenoma. This can be remembered as follows metanephric adenoma is a tumour.
General
- Benign.
- Afflicts adults and occasionally children.
- May be associated with polycythemia.[1]
Microscopic
Features:[2]
- Small uniform cells with:
- Fine chromatin.
- No apparent nucleolus.
- A relatively smooth nuclear membrane.
- Variable architecture - may be sheets or ductal.
DDx:
- Epithelioid nephroblastoma (Wilms tumour) - these typically have:
- Irregular nuclear membrane.
- Nucleoli.
- Mitoses (rare in metanephric adenoma).
- Papillary RCC.[2]
Images
Metanephric adenoma (WC/Nephron)
Metanephric adenoma - cropped (WC/Nephron)
Metanephric adenoma - PaRCC-like - intermed. mag. (WC/Nephron)
Metanephric adenoma - PaRCC-like - very high mag. (WC/Nephron)
www:
IHC
See also
References
- ↑ Le Nué, R.; Marcellin, L.; Ripepi, M.; Henry, C.; Kretz, JM.; Geiss, S. (Aug 2011). "Conservative treatment of metanephric adenoma. A case report and review of the literature.". J Pediatr Urol 7 (4): 399-403. doi:10.1016/j.jpurol.2010.09.010. PMID 21220212.
- ↑ 2.0 2.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 284. ISBN 978-0781765275.
- ↑ 3.0 3.1 3.2 Watanabe, S.; Naganuma, H.; Shimizu, M.; Ota, S.; Murata, S.; Nihei, N.; Matsushima, J.; Mikami, S. et al. (2013). "Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases.". Case Rep Pathol 2013: 675875. doi:10.1155/2013/675875. PMID 24083046.
.