48,479
edits
Difference between revisions of "Lynch syndrome"
Jump to navigation
Jump to search
→Muir-Torre syndrome
(→Special types: expand a bit) |
|||
| Line 43: | Line 43: | ||
*Abbreviated ''MTS''. | *Abbreviated ''MTS''. | ||
*Muir-Torre syndrome is a subset of HNPCC that includes the presence of [[sebaceous adenoma]]s,<ref>{{Ref PBoD8|1177}}</ref> and [[sebaceous carcinoma]]s.<ref name=pmid2029018>{{Cite journal | last1 = Cohen | first1 = PR. | last2 = Kohn | first2 = SR. | last3 = Kurzrock | first3 = R. | title = Association of sebaceous gland tumors and internal malignancy: the Muir-Torre syndrome. | journal = Am J Med | volume = 90 | issue = 5 | pages = 606-13 | month = May | year = 1991 | doi = | PMID = 2029018 }}</ref> | *Muir-Torre syndrome is a subset of HNPCC that includes the presence of [[sebaceous adenoma]]s,<ref name=PBoD8_1177>{{Ref PBoD8|1177}}</ref> and [[sebaceous carcinoma]]s.<ref name=pmid2029018>{{Cite journal | last1 = Cohen | first1 = PR. | last2 = Kohn | first2 = SR. | last3 = Kurzrock | first3 = R. | title = Association of sebaceous gland tumors and internal malignancy: the Muir-Torre syndrome. | journal = Am J Med | volume = 90 | issue = 5 | pages = 606-13 | month = May | year = 1991 | doi = | PMID = 2029018 }}</ref> | ||
** | **Cutaneous pathology precedes the internal malignancy in ~40% of cases.<ref name=pmid2029018/> | ||
Molecular pathology: | |||
*MTS is caused by mutations in MSH2 or MLH1.<ref name=omim158320>{{OMIM|158320}}</ref> | |||
==See also== | ==See also== | ||