Difference between revisions of "Rheumatoid arthritis"
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=Ref_DCHH299>{{Ref DCHH|299}}</ref> | Features:<ref name=Ref_DCHH299>{{Ref DCHH|299}}</ref><ref name=Ref_Derm52>{{Ref Derm|52}}</ref> | ||
*Necrotic collagen bundles with | *Necrotic collagen bundles with fibrin surrounded by: | ||
**Palisading [[granuloma]]. | **Palisading [[granuloma]]. | ||
*+/-Eosinophils. | *+/-Eosinophils. | ||
Notes: | Notes: | ||
*Histomorphologically | *Histomorphologically very similar to ''[[Granuloma annulare]]''. | ||
DDx: | DDx: | ||
*[[Granuloma annulare]]. | *[[Granuloma annulare]] - has mucin in the core of the granuloma.<ref name=Ref_Derm52>{{Ref Derm|52}}</ref> | ||
*[[Necrobiosis lipoidica]]. | *[[Necrobiosis lipoidica]]. | ||
Revision as of 20:36, 29 January 2012
Rheumatoid arthritis, commonly abbreviated RA, is an autoimmune disorder.
Skin
General
- May manifest as rheumatoid neutrophilic dermatitis - super rare.[1]
Microscopic
Features:
- Nodular and diffuse pattern.
- Neutrophils.
Joints
Main article: Joints
Microscopic
Features:
- Chronic inflammation (e.g. lymphocytes).
Images:
Rheumatoid nodule
General
- Usually only in seropositive cases.[3]
Microscopic
- Necrotic collagen bundles with fibrin surrounded by:
- Palisading granuloma.
- +/-Eosinophils.
Notes:
- Histomorphologically very similar to Granuloma annulare.
DDx:
- Granuloma annulare - has mucin in the core of the granuloma.[4]
- Necrobiosis lipoidica.
Images:
- Rheumatoid nodule (granuloma.homestead.com).[5]
- Rheumatoid nodule (granuloma.homestead.com).[5]
- Rheumatoid nodule (utah.edu).[6]
Lung disease
- See Medical lung disease.
RA may involve the lung.
Amyloidosis
- See Amyloidosis.
Amyloidosis may be due to RA.
Felty syndrome
RA may occur in Felty syndrome -- the triad:[7]
- Rheumatoid arthritis.
- Splenomegaly.
- Neutropenia.
Felty syndrome is assoc. with large granular lymphocytic leukemia.[7]
See also
References
- ↑ Mashek, HA.; Pham, CT.; Helm, TN.; Klaus, M. (Jun 1997). "Rheumatoid neutrophilic dermatitis.". Arch Dermatol 133 (6): 757-60. PMID 9197831.
- ↑ URL: http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/msfrm.html. Accessed on: 5 December 2010.
- ↑ 3.0 3.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 299. ISBN 978-0470519035.
- ↑ 4.0 4.1 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 52. ISBN 978-0443066542.
- ↑ 5.0 5.1 URL: http://granuloma.homestead.com/palisading.html. Accessed on: 1 November 2010.
- ↑ URL: http://www.pathguy.com/lectures/joints.htm. Accessed on: 1 November 2010.
- ↑ 7.0 7.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 328. ISBN 978-1416054542.