Difference between revisions of "Paraganglioma"

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*EMA -ve.
*EMA -ve.
**+ve in RCC.
**+ve in RCC.
==EM==
Features:
*Neurosecretory granules.
Image:
*[http://path.upmc.edu/cases/case408/images/fig14.jpg Neurosecretory granules (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case408.html http://path.upmc.edu/cases/case408.html]. Accessed on: 16 January 2012.</ref>


==See also==
==See also==

Revision as of 04:31, 17 January 2012

Paraganglioma is a rare tumour arising from the paraganglion. A paraganglioma arising in the adrenal gland is known as a pheochromocytoma.

General

  • Definition: tumour of paraganglion.
    • Can be sympathetic or parasympathetic.
  • Most common paraganglioma = pheochromocytoma.[1]
    • Head & neck most common site - after abdomen.
  • Carotid body tumour = paraganglioma of carotid body.

Epidemiology

Clinical

  • 10% bilateral, multiple, familial, pediatric and malignant.[3]

Microscopic

Features:[4]

  • Zellballen (literally: "cell balls") - nests of cells.
  • Fibrovascular septae.
  • Finely granular cytoplasm (salt-and-pepper nuclei).
  • +/-Hemorrhage - very common.

Images:

IHC

Features:[5]

  • Chromogranin +ve.
  • Synaptophysin +ve.
  • S100 +/-.
  • Cytokeratin -ve.
  • EMA -ve.
    • +ve in RCC.

EM

Features:

  • Neurosecretory granules.

Image:

See also

References

  1. Thompson, Lester D. R. (2006). Endocrine Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 327. ISBN 978-0443066856.
  2. Thompson, Lester D. R. (2006). Endocrine Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 328. ISBN 978-0443066856.
  3. Thompson, Lester D. R. (2006). Endocrine Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 327. ISBN 978-0443066856.
  4. Thompson, Lester D. R. (2006). Endocrine Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 329-332. ISBN 978-0443066856.
  5. Thompson, Lester D. R. (2006). Endocrine Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 335. ISBN 978-0443066856.
  6. URL: http://path.upmc.edu/cases/case408.html. Accessed on: 16 January 2012.